Absorption and Covalent Coupling of ATP Aptamers onto Cellulose, 2006 PLACE Conference

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Paper is extensively used as a barrier for protection from pathogens in applications such as medical face masks and protective clothing reflecting the fact that paper is inexpensive, disposable, autoclavable and can have well defined porosity. Nevertheless, in most protective applications, paper functions simply as a passive barrier or filter. Recognizing that the there is an opportunity to improve the functionality of paper, a network of Canadian academic researchers have embarked on a research program to develop “bioactive paper” which we define as paper which can which detect and repel or deactivate waterborne and airborne pathogens. A key requirement for bioactive paper is the presence of bio-recognition molecules coupled to a signaling mechanism on paper surfaces. Antibody fragments and enzymes are the most common bio-recognition agents, however, these molecules are usually very fragile and would deteriorate when dried out on a paper surface. By contrast, DNA aptamers are far more robust and thus hold promise as paper-supported bio-sensing agents.