Braiding Electrospun Nanofibers for Tendon/Ligament Tissue Engineering, 2011 Innovative Nonwovens Conference



ARE YOU A TAPPI MEMBER? TAPPI members have exclusive, FREE access to technical conference papers and presentations six months after the conference in TAPPI's e-library. The e-Library offers:

  • Unlimited access to more than 18,000+ documents
  • Fast, robust search engine for fast search results
  • Members get FREE access to conference proceedings, TAPPI JOURNAL articles, Paper360º articles, archived Solutions! articles, and much more
  • View thousands of technical paper abstracts
  • Ability to search by keyword, title, author, events or industry segment

*Technical papers and presentations are available for sale immediately following the conferences before the 6 month embargo period.

Please Note: This document will be available in PDF format in the "My Electronic Documents" link on the home page once your order has been completed. Please make sure you have the latest version of Acrobat Reader. Click on the Acrobat Reader icon to check for the latest version, it’s FREE. To print a hardcopy of a PDF file correctly you must have a postscript printer. If you are not sure if your printer is a postscript printer please refer to your owner’s manual.

Purchase of electronic (downloadable) documents made at www.tappi.org by credit cards, followed by instant download CANNOT be cancelled. We do not offer refunds on electronic download documents.

Tissue engineering is a promising solution to tissue or organ shortage. To achieve the tissue engineering goal, it is critical to use a biomaterial scaffold that has favorable mechanical and biological properties to culture cells for tissue regeneration. In this study, we explored the potential of a unique braided nanofibrous scaffold (BNFS) that is composed of aligned electrospun nanofiber bundles for tendon/ligament tissue engineering. We braided multiple aligned nanofiber bundles into a three-dimensional structure to enhance mechanical properties of the scaffold, and then cultured human mesenchymal stem cells (hMSCs) in the scaffold and stimulated with tensile loading to induce tendon/ligament regeneration. Our hypothesis is that the unique BNFS can effectively induce hMSC differentiation and extracellular matrix (ECM) synthesis to produce mechanically, structurally, and biologically functional tendon/ligament grafts. Our results showed that structural properties of BNFSs were dependent on fabrication parameters, such as the number of braided fiber bundles. Cells cultured in the braided scaffolds continued to proliferate and produced tendon/ligament ECM during the culture period. Interestingly, the fibrous structure of the scaffold effectively oriented cells and cytoskeleton organization for favorable biological response. Taken together, this study demonstrates the potential of a novel BNF for functional tendon/ligament tissue engineering.

Author: Wan-Ju Li, John G. Barber, Andrew M. Handorf
Braiding Electrospun Nanofibers for Tendon/Ligament Tissue E
Braiding Electrospun Nanofibers for Tendon/Ligament Tissue Engineering, 2011 Innovative Nonwovens Conference
30.00

New Releases

 

Kraft Recovery Boilers, Third Edition  


Sponsored by the Recovery Boiler Program R&D Subcommittee of the American Forest & Paper Association (AF&PA) and published by TAPPI Press.


Purchase


 

Handbook For Pulp and Paper Technologists (The SMOOK Book), Fourth Edition

The best-selling text to introduce the entire technology of pulp and paper manufacture.

Purchase

 

Guidelines for Safe Assessment and Operation of Yankee Dryers  


A project of the Yankee Dryer Safety & Reliability Committee.

Purchase

 

Check our newest additions.


TAPPI Press offers some of the most in-depth resources and references for the forest products and related industries. 

See More

   
 

Available for Purchase – Conference Proceedings


TAPPI maintains a record of key conference papers, presentations, and other conference publications, available for purchase in a variety of formats.

See More