Evaluation of rice straw for purification of lovastatin, TAPPI Journal November 2021



Application: This study devised a process for producing lovastatin in its pure form from a culture of Aspergillus terreus ATCC 20542, and a new extraction procedure was designed for the isolation of lovastatin.

TAPPI conference proceedings and presentations, technical papers, and publication articles provide technical and management data and solutions on topics covering the Pulp, Paper, Tissue, Corrugated Packaging, Flexible Packaging, Nanotechnology and Converting Industries.

Simply select the quantity, add to your cart and your conference paper, presentation or article will be available for immediate download.

Author: Wen-Ta Su and Chin-Chuan Yi
Evaluation of rice straw for purification of lovastatin, TAP
ABSTRACT: Cholesterol synthesis in the human body can be catalyzed by the coenzyme HMG-CoA reductase, and lovastatin, a key enzyme inhibitor, can reduce hypercholesterolemia. Lovastatin can be obtained as a secondary metabolite of Aspergillus terreus ATCC 20542. In this study, rice straw of lignocellulose was used in aeration and agitation bath fermentation in a 1-L flask, and a maximal crude extraction rate of 473 mg/L lovastatin was obtained. The crude extract was treated with silica gel (230•400 mesh) column chromatography. Ethyl acetate/ethanol (95%) was used as the mobile phase, and isolation was performed through elution with various ethyl acetate/ethanol ratios. The highest production rate of 153 mg/L was achieved with ethyl acetate/ethanol in a ratio of 8:2. The lovastatin gained from the crude extract was added to 12 fractions treated with 0.001 N alkali, and acetone was then added. After 24 h of recrystallization at 4°C, the extract underwent high-performance liquid chromatography. The purity had increased from 25% to 84.6%, and the recovery rate was 65.2%.
0.00

New Releases

TAPPI PRESS Catalog eBook 2024


Experience the Power of Publications in the 2024 TAPPI Press Catalog


Open
 

Kraft Recovery Boilers, Third Edition  


Sponsored by the Recovery Boiler Program R&D Subcommittee of the American Forest & Paper Association (AF&PA) and published by TAPPI Press.


Purchase
 

Handbook For Pulp and Paper Technologists (The SMOOK Book), Fourth Edition

The best-selling text to introduce the entire technology of pulp and paper manufacture.

Purchase
 

Guidelines for Safe Assessment and Operation of Yankee Dryers  


A project of the Yankee Dryer Safety & Reliability Committee.

Purchase
 

Check our newest additions.


TAPPI Press offers some of the most in-depth resources and references for the forest products and related industries. 

See More
   
 

Available for Purchase – Conference Proceedings


TAPPI maintains a record of key conference papers, presentations, and other conference publications, available for purchase in a variety of formats.

See More