Labeled Cellulose for EHS Studies, TAPPICon25

Celluloses have been used in a growing number of applications due to their abundance, non-toxicity, chemical stability, and structural properties. These applications include use as food additives, pharmaceuticals, and medical implants or scaffolds. In all these applications, the effects on environmental and health safety (EHS) are extremely important to characterize. To examine cellulose migration and EHS effects, the cellulose must be distinguished from other biological materials. New cellulose modifications and new forms of cellulose require regulatory examination as engineered materials, especially for food and medical applications. In this study, we examine the chemistry of cellulose trace labeling using either fluorescent or isotopic labels. The use of fluorescent (e.g. DTAF or BODIPY) and isotopic (e.g. 13C or 14C) labels increases the limit of detection (lower concentrations) and distinguishes the cellulose from other biological materials. However, care must be taken when choosing the appropriate label and labeling protocol, as physisorption of free dye, bond instability, pH sensitivity, removal of by-products, lignin interference, minimization of surface charge changes, and maintenance of initial morphology all present major challenges, especially for smaller and/or charged forms of cellulose, such as cellulose nanocrystals. Here, we present an overview of best methods to label celluloses, depending on the cellulose form and intended application.

TAPPI conference proceedings and presentations, technical papers, and publication articles provide technical and management data and solutions on topics covering the Pulp, Paper, Tissue, Corrugated Packaging, Flexible Packaging, Nanotechnology and Converting Industries.

Simply select the quantity, add to your cart and your conference paper, presentation or article will be available for immediate download.