Current Approaches in Leak Testing Pharmaceutical Packages, 1996 Polymers, Laminations & Coatings Conference Proceedings
Methods for detecting and quantitating leakage vary from the most simple to much more expensive techniques which are highly discriminating and sophisticated. An overview of leak test methods used for a variety of pharmaceutical dosage form package types will be presented along with some advantages and disadvantages of each. Because no, leak test method is perfect, the selection process can be frustrating and at times confusing. The examples given will be discussed in light of the leakage specifications deemed critical for given product/package configurations.